I came across this video podcast called シコウヒンTV. Their website is http://www.450hin.tv/

Is there some way in which "450" can be pronounced "シコウ"? I see how "4" is "シ" but what about the rest of it?

Think of it as:
4: し
5: ご
0: Oh (as in four five oh)

shigo+Oh
shigou